Rabeprazole | Structure | Synthesis |MOA| uses| dosage | Side-effects

 Rabeprazole 

  Rabeprazole is an antiulcer drug and a member of benzimidazoles and pyridines. It is also a Proton pump inhibitor. It is white and crystalline in nature. Rabeprazole is very solluble in water and methanol, freely solluble in alcohol, chloroform and ethyl acetate, insolluble in ether and n-hexane. The moleculer weight of rabeprazole is 359.4 g/mol and melting point is 99-100⁰c. It is also known as Aciphex,Pariets,Sodium Rabeprazole, Rabelon.

■Structure:-

The moleculer formula of rabeprazole is, 

                                                                    [C18H21N3O3S]

The IUPAC name of rabeprazole is, 

2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl sulfinyl]-1H-benzimidazole

■Synthesis:-

■Mechanism of action:-

    It is an antisecratory compound and having histamine H2 receptor antagonist properties. It inhibits the gastric H+/K+/ATPase at the surface of the parietal cell, due to this its blocks the final step of gastric acid secretion. Rabeprazole chemically activated at pH1.2 with a half life of 78 seconds. 

■Uses:-

Rabeprazole is used in the treatment of, 

• Duodenal ulcer. 
• Gastric ulcer. 
• Gastroesophageal reflux disease. 
• Zollinger-ellison syndromes. 
• Helicobactor pylori infections 

■Dosage:-

For duodenal ulcer the usual adult dose is 20mg orally per day for 4 weeks after morning meal.

For gastroesophageal reflux disease the usual adult dose is 20mg orally once a day for 4-8 weeks. The maintainance dose is 20mg orally per day for upto 2 months.

For the treatment of Zollinger-ellison syndromes the usual initial dose is 60mg orally per day for 4-8 weeks. 

■Side-effects:-

• Bloating and swelling face,arms,hands or feet.
• Tiredness and weekness.
• Rapid weight gain. 
• Unusual weight loss. 
• Yellow eyes or skin.
• Tingling of the hands or feet.

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