Exploring the Composition, Mechanism of Action, Benefits, Safety Instruction of Acebrophylline + Montelukast Sodium Tablets

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 Introduction:

Acebrophylline and Montelukast are two pharmaceutical agents that, when combined in a single tablet, are used for the treatment of respiratory conditions. This combination, addresses both bronchodilator and anti-inflammatory needs, making it a valuable option for individuals with respiratory disorders. Let's delve into the composition, mechanism of action, uses, side effects, and safety instructions associated with this pharmaceutical combination.

Composition:

This tablet contains two drugs, Acebrophylline and Montelukast sodium,

• Acebrophylline: Acebrophylline is a xanthine derivative. It contains Theophylline and Ambroxol. So, it has both bronchodilator and muco regulatory properties. It is a white crystalline powder. It is used for lung diseases like asthma and COPD (Chronic Obstructive Pulmonary Disease). The molecular weight of acebrophylline is 616.3 gm/mol. The molecular formula of acebrophylline is, C­­­­­22H28N6O5Br2.

  

  Acebrophylline Structure

• Montelukast Sodium: Montelukast Sodium is an Antiasthmatic(add-on therapy for mild to moderate asthma). It is a leukotriene receptor antagonist. Montelukast sodium is a white to pale yellow powder, freely soluble in ethanol (95%), methanol, and water; and practically insoluble in acetonitrile. The molecular weight of montelukast sodium is 608.2 gm/mol. The molecular formula of montelukast sodium is, C­­­­­35H35NNa2O₃SCl.

  

  Montelukast Sodium Structure

Mechanism of Action:

• Acebrophylline: Acebrophylline inhibits mucus secretion by decreasing the viscosity of the mucus making it smooth to cough up. It works by inhibiting phosphodiesterase, leading to increased levels of intracellular cyclic AMP, which, in turn, results in bronchodilation and reduced airway inflammation. It also relaxes the airway's smooth muscle, which helps for comfortable breathing.

• Montelukast Sodium: Montelukast is a leukotriene receptor antagonist. It binds with the CysLT type 1 receptor, due to this the physiological actions of CysLTs like LTC4, LTD4, and LTE4 are blocked. These leukotriene receptors are responsible for the symptoms of asthma or allergic rhinitis.

Uses:

• Asthma Management: The combination of Acebrophylline and Montelukast Sodium is very effective against asthmatic symptoms. Acebrophylline helps in the contraction of airway smooth muscles, while Montelukast Sodium targets the underlying inflammatory processes, resulting in improved asthma control and reduced exacerbations.

• Chronic Obstructive Pulmonary diseases: This tablet is used for patients who have experienced airway obstruction and increased mucus production.

• Bronchitis: Acebrophylline and Montelukast Sodium tablets are used in the treatment of bronchitis, especially when associated with excessive mucus production and airway inflammation. The combination helps ease breathing difficulties, reduce cough, and promote recovery from acute exacerbations.

• Allergic Rhinitis: Montelukast Sodium's role in blocking leukotrienes makes it effective in treating allergic rhinitis symptoms such as nasal congestion, sneezing, and itching.

Adverse effects:

Most of the time this pharmaceutical combination does not show any adverse effects, but in some cases, it shows adverse effects like fever, headache, diarrhea, abdominal pain, nausea, dizziness, respiratory infections, constipation, feeling sleepy, etc.

Safety Instruction:

• Acebrophylline and Montelukast Sodium tablets are schedule-H drugs, so they should only be used with a valid prescription from a qualified healthcare professional.
• Patients should follow their healthcare provider's instructions regarding dosage, administration frequency, and treatment duration. 
• Regular use of this tablet may cause adverse effects.

Conclusion:

 Acebrophylline and Montelukast Sodium tablets offer a comprehensive approach to managing respiratory conditions by addressing bronchodilators, inflammation, mucus clearance, and symptom control. Their mechanism of action makes them effective in conditions like asthma, COPD (Chronic Obstructive Pulmonary diseases), bronchitis, and allergic rhinitis, providing patients with relief from respiratory distress and improving their overall respiratory health. However, it's essential to use these medications under medical supervision and follow prescribed dosages for optimal therapeutic outcomes.