Miconazole|Structure|Synthesis|Mechanism of Action|Uses|Side-effects|Minostate|Miconazolum|Daktarin IV|Vusion

 Miconazole

Miconazole is an imidazole derrivative anti-fungal agent. It is used in the treatment of Athlete's foot and Jock itch. It is a broad-spectrum azole antifungal agent. The molecular weight of miconazole is 416.1gm/mol.It is also known as, Minostate, Miconazolum ,Daktarin IV ,Vusion etc.

Structure:-

The moleculer formula of miconazole is,[C18H14Cl4N2O].

The IUPAC name of miconazole is,1-[2-(2,4-dichlorophenyl)-2-[(2-(2,4-dichlorophenyl)methoxy]ethyl]imidazole.

Synthesis:-

Mechanism of Action:-

Miconazole binds with 14alpha-sterol demethylase. This 14-alpha-sterol demethylase is an essential enzyme of fungal cell membranes. This is the cytochrome P450 enzyme, which converts lanosterol to ergosterol. Miconazole increased cellular permeability by inhibiting ergosterol synthesis. When the cellular permeability is increased the cellular contents leak out and then the cell is dead.

Uses:-

It is used in the treatment of pityriasis Versicolor and Cutaneous candidiasis.

It is also used to treat Jock itch caused by Trichophyton mentagrophytis and Athletes foot caused by Trichophyton rubrum.

Side-effects:-

The overdose of miconazole shows different types of adverse effects like, 

1. Burning, itching, and pain in the vagina and urinary tract.

2. Pimple-like bumps.

3. Redness.

4. Headache.

5. Itching.

6. Stinging.

7. Swelling.

8.Pain or flaking on skin.

9. Tenderness.

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