Benzatropine|Benztropine|Cogentin|Structure|Synthesis|MOA|Uses|Side-effects

  

 Benzatropine

Benzatropine is an anti-muscarinic and anti-cholinergic drug, which is used in the treatment of Parkinsonism and  Dystonia. The brand name of benzatropine is Cogentin. It is also known as benztropine in the US and Japan. Benzatropine also contains antihistamine activity. Benzatropine is a white crystalline solid, which is highly soluble in water. The molecular weight of benzatropin is 307.43 gm/mol.

Structure:

The molecular formula of benzatropin is, [C­­­­­21H25NO].

Benzatropine structure

The IUPAC name of benzatropin is Benzhydryloxy-8-mrthyl-8-azabicyclo[3.2.1]octane.

Synthesis:

Benzatropine synthesis

Mechanism of action:

Benzatropine blocks acetylcholine. Acetylcholine is a neurotransmitter that transfers the nerve signal from one neuron to another. When it blocks acetylcholine it reduces central cholinergic effects in CNS. It also inhibits dopamine reuptake. Dopamine is a neuromodulator that plays an important role in the brain. Due to the inhibition, the movement of brain muscles is smooth.

Uses:

• It is used to treat the symptoms of Parkinson's disease.
• It decreases muscle stiffness.
• Used to treat muscle spasms (Back and Neck).
• It is not for treating movement problems caused by dyskinesia.

Side-effects:

The overdose of benzatropin shows different types of side effects like,

• Constipation.
• Blur vision.
• Dry mouth.
• Drowsiness.
• Loss of appetite.
• Nervousness.
• Painful urination.
• Vomiting and nausea.