Trimethoprim|Structure|Synthesis|Mechanism of action|Uses|Side-effect|Minoprim|Trimpex|Bactramin|Trimopan|Wellcoprim|Uretrime

  

 Trimethoprim

Trimethoprim is a dihydrofolate reductase inhibitor. It contains antibacterial and antiprotozoal properties. It is a synthetic derivative of trimethoxybenzyl pyrimidine. Trimethoprim is a white, odorless, bitter taste powder. The molecular weight of trimethoprim is 290.3 gm/mol. It is slightly soluble in water and alcohol. It is also known as, Minoprim, Trimpex, Bactramin, Trimopan, Wellcoprim, Uretrime, etc.

Structure:

The molecular formula of trimethoprim is, [C14H18N4O3].

The IUPAC name of trimethoprim is 5-[(3,4,5-tri methoxyphenyl)methyl]pyrimidine-2,4-diamine.

Synthesis:

Mechanism of action:

Trimethoprim prevents dihydrofolic acid (DHF) to Tetrahydrofolic acid (THF) conversion by inhibiting hydro folate reductase enzyme, in the thymidine synthesis pathway. This pathway inhibits bacterial DNA synthesis.

Uses:

Trimethoprim is an antibiotic, that prevents the growth of bacteria so it is used for bacterial infection. it is used in the treatment of UTIs (Urinary tract infections) like cystitis and it is also used in the treatment of chest infections.

Side-effects:

The overdose of trimethoprim shows several types of side-effects,

1. Stomach upset.
2. Loss of appetite.
3. Headache.
4. Nausea.
5. Vomiting.
6. Rashes.
7. Changes in taste.
8. Fever.
9. Skin sensitivity to light.