Albuterol|Salbutamol|Structure|Synthesis|Mechanism of action|Uses|Side-effects|Emican|Fartolin|Ventolin|Alprol|Broncodil|Loftan|Epaq

  

 Albuterol/Salbutamol

Albuterol is a beta2 adrenergic drug. WHO recommended the name for albuterol is salbutamol. It is a bronchodilator, which is used in the treatment of asthma and COPD. It relaxes the airway's smooth muscle. It is an ethanolamine sulfate salt. Albuterol is a white crystalline powder that is soluble in water and slightly soluble in ethanol. The molecular weight of albuterol is 576.7 gm/mol. It is also known as, Emican, Fartolin, Ventolin, Alprol, Broncodil, Loftan, Ipaq, etc.

Structure:

The molecular formula of albuterol is,[C13H21NO3].

The IUPAC name of albuterol is, 4-[2-(tert-butylamino)-1-hydroxy ethyl]-2-(hydroxymethyl)phenol.

Synthesis:

Mechanism of action:

Albuterol or salbutamol is the beta2 adrenergic receptor, which relaxes the airway smooth muscle. The beta2 adrenergic receptors have increased the concentration of cyclic AMP (cyclic-3',5'-adenosine monophosphate). Due to this the protein kinase is activated which inhibits the phosphorylation of myosin and lower intracellular ionic calcium concentration resulting in the relaxation of airway smooth muscle.

Uses:

It is used in the treatment of asthma and COPD like wheezing, difficulty breathing, chest tightness, coughing, etc.

Side-effects:

The overdose of albuterol shows different types of side effects like,

• Rapid heart rate (tachycardia).
• Muscle aches.
• Palpitations.
• Nervousness.
• Headache.
• Throat and nasal irritation.