Spironolactone|Structure|Synthesis|Mechanism of action|Uses|Side-effects|Aldactone|Uractons|Verospirin|Alderon|Aldace

    

 Spironolactone

It is a corticosteroid, diuretic, and aldosterone receptor antagonist. It is used in the treatment of liver scarring, kidney diseases, etc. Spironolactone is a light cream-colored crystalline solid that is soluble in water and ethanol, and slightly soluble in methanol. The boiling point of spironolactone is 134℃ temp. The molecular weight of spironolactone is  416.6 gm/mol. It is also known as, Aldactone, Uractons, Verospirin, Alderon, Aldace, etc.

Structure:

The molecular formula of spironolactone is, [C24H32O4S].

The IUPAC name of spironolactone is, S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5`-dixospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta phenantherene-17,2`-oxolane]-7-yl] ethane thioate.

Synthesis:

The industrial method of spironolactone synthesis is,

Mechanism of action:

It is an aldosterone receptor antagonist and a diuretic. It binds with the aldosterone receptor and increases the amount of sodium and water excretion in our body but retains the potassium ion.

Uses:

It is used in the treatment of hypertension, heart failure, and kidney problems, prevent stroke and heart attacks.

Side-effects:

The overdose of spironolactone shows different types of side effects like,

1. Dizziness.
2. Headache.
3. Light head ness.
4. Extreme thirst.
5. Vomiting.
6. Muscle weakness.
7. Weak pulse.
8. Coughing up blood.
9. Diarrhea.
10. Increased urination.