Tolnaftate|Structure|Synthesis|Mechanism of action|Uses|Side-effects|Tonoftal,Tolsanil,Tritin,Fungistop,Phytoderm,Pitrex,Dermoxin,Tinactin
Tolnaftate
Tolnaftate is a synthetic Over-The-Counter (OTC) anti-fungal agent. Tolnaftate is used in the treatment of Ringworm, Jock itch and Athlete's foot diseases. It is derrived from 2-napthol. It is available in many dosage from like, powder, spray, liquid aerosol's, creams etc. Normally it is white crystalline powder. The melting point of tolnaftate is 231 to 232.7 degree F. It is also known as,Tonoftal, Tolsanil, Tritin, Fungistop, Phytoderm, Pitrex, Dermoxin, Tinactin etc.
Structure:-
The moleculer formula of tolnaftate, [C19H17NOS].
The IUPAC name of tolnaftate is, O-napthalen-2-yl-N-methyl-N-(3-methylphenyl)carbamothioate.
Synthesis:-
Mechanism of Action:-
The mechanism of action of tolnaftate is not clear. It's have topical fungicidal and fungistatic properties. Tolnaftate inhibits the squalene epoxidase enzyme. Due to the inhibition of biosynthesis of ergosterol is stop. Ergosterol is an essential component of fungal cell membren. So the cell is dead.
Uses:-
1. It is used in the treatment of Ringworm infection, Athlete's foot and Jock itch.
2.It is used to treat fungal infections of nails,palm and sole's foot.
Side-effects:-
The overdose of tolnaftate shows different types of adverse effects like, dificulty in breathing, swelling of face, hives, dryness of skin, itching etc.When this types of problems shows than contact to your doctor.
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