Griseofulvin|Structure|Mechanism of action|Uses|Side-effects|Fulvicin|Fulcine|Griseofulvinum|Spirofulvin|Grizeofulvin|Likuden|Murfulvin|Grisetin|Biogrisin-FP|Amudane

 Griseofulvin 

Griseofulvin is an antifungal agent. It is used in the treatment of several types of dermatophytos

-is. It is odorless, tasteless and appears creamy coloured crystalline powder. It is insolluble in water and slightly solluble in aceton, benzene, methanol etc. It is derrived from Penicillum griseofulvin. The moleculer weight of griseofulvin is 352.8 gm/mol.It is also known as, Fulvicin,Fulcine,Griseofulvinum,Spirofulvin, Grizeofulvin, Likuden, Murfulvin, Grisetin, Biogrisin-FP, Amudane etc.

■Structure:-

The moleculer formula of griseofulvin is, 

                                                         [C17H17ClO6].

The IUPAC name of griseofulvin, 

(2S,5'R)-7-chloro-3',4,6-trimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione.

■Mechanism of action:-

The exact mechanism of action of griseofulvin is not clear. When its reach the fungal site of action, it binds to microtubes of fungus and disrupts the fungal cell mitosis and inhibit nuclear acid synthesis. It also interfere in the function of spindle and cytoplasmic  microtubules by binding  to alpha and beta tubulin. After reaching the fungal site of action, it binds to keratin in human in human cells.

■Uses:-

• It is used in the treatment of ringworm infections skin, hair and nails.
• It also used to treat jock itch and athletes foot.

■Side-effects:-

The overdose of griseofulvin show different types of adverss effect. 

1. Dark urine.
2. Fever.
3. Feeling tired.
4. Diarrhoea. 
5. Dizziness. 
6. Insomnia.
7. Hives.
8. Headache. 
9. Loss of appetite. 
10. Rash.
11. Skin pain.
12. Vomiting. 
13. Jaundice. 
14. Fatigue.

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