Indinavir
Indinavir is an antiviral drug and an HIV protease inhibitor. Indinavir is used in the treatment of Human Immunodeficiency Virus infections. It is a white to off-white crystalline powder. It is a synthetic hydroxy aminopentane amide agent. The molecular weight of Indinavir is 613.7 gm/mol and the melting point is 167-168⁰c. It is also known as Grixivan.
■Structure:-
The molecular formula of indinavir is,
[C36H47N5O4].
The IUPAC name of indinavir is,
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-{{(1S,2R)-2-hydroxy-2,3-dihydro-1-inden-1-yl}amino}-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide.
■Mechanism of action:-
This drug works by preventing the cleavage process of gag-pol polyproteins by inhibiting the viral protease enzyme, resulting in immature, noninfectious viral particles.
■Dosage:-
For treating HIV infections, indinavir is taken with ritonavir, in which the initial indinavir dose is 800mg and the initial ritonavir dose is 100-200mg. It is taken twice daily in a gap of every 12 hours.
■Uses:-
Along with other anti-HIV drugs indinavir is used to treat Acquired Immunodeficiency Syndrome caused by Human Immunodeficiency Virus.
■Side-effects:-
The overdose of indinavir shows several Side-effects like, hemolytic anemia, abdominal pain, nausea, vomiting, diarrhea, kidney stones, fatigue, lipodystrophy, hyperglycemia, etc.
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