Bisoprolol Fumarate|Structure|Synthesis|MOA|Uses|Side-effects

  

 Bisoprolol Fumarate

Bisoprolol fumarate is a beta-1 receptor blocker. It is a propane-2-ol derivative that is used in the treatment of hypertension. It is sold under the brand name Zebeta. The molecular weight of bisoprolol fumarate is 767.0 gm/mol. It is a white crystalline powder, which is very soluble in water.

Structure:

The molecular formula of bisoprolol fumarate is, [C­­­­­40H66N2O12].

Bisoprolol Structure

The IUPAC name of bisoprolol fumarate is,(2E)-but-2-ene dioic acid, bis (1-[(propan-2-yl)amino]-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propan-2-ol).

Synthesis:

Bisoprolol  Synthesis

Mechanism of action:

Bisoprolol fumarate is a cardioselective blocker. It blocks the beta-1 receptor. Due to this ATP is not converted into cAMP. This cAMP is responsible for the production of protein kinase-A, which increased calcium ion levels in the human body. This calcium ion is responsible for the contraction of cardiac muscle. Bisoprolol fumarate blocks the conversion process of ATP to cAMP, so the cardiac stimulations are reduced.

Uses:

It is used in the treatment of high blood pressure(Hypertension). It is also used to prevent heart attacks and strokes. It is also used in the treatment of several kidney problems.

Side-effects:

The overdose of bisoprolol fumarate shows different types of side effects like,

1. Anxiety.
2. Dizziness.
3. Nausea.
4. Vomiting.
5. Low heart rate.
6. Weakness.
7. Skin rash.
8. Itching.
9. Headache.
10. Tiredness.