Brompheniramine|Dimetapp|Structure|Synthesis|MOA|Uses|Side-effects

  

 Brompheniramine 

Brompheniramine is a first-generation histamine1 receptor antagonist. It is sold under the brand name Dimetapp among others.   It is used in the treatment of allergic conditions. It is an odorless, white, crystalline powder, which is freely soluble in water, soluble in chloroform, and benzene. Brompheniramine is very light-sensitive. the molecular weight of 319.24 gm/mol.

Structure:

The molecular formula of brompheniramine is, [C­­­­­16H19N2Br].

Brompheniramine Structure

The IUPAC name of brompheniramine is, (R/S)-3-(4-bromophenyl)-N, N-dimethyl-3-pyridin-2-yl-propan-1-amine.

Synthesis:

Brompheniramine Synthesis

Mechanism of action:

It is a first-generation Histamine1 receptor antagonist, which blocks the production of histamine. Due to this, the allergic symptoms caused by histamine are reduced.

Uses:

It is used in the treatment of Common cold, Hay fever, Cough, Headache, and Sinus pain.

Side-effects:

The overdose of brompheniramine shows different types of side effects like,

1. Constipation.
2. Dry mouth, nose, and throat.
3. Difficulty in breathing.
4. Little or no urination.
5. Dizziness.
6. Drowsiness.
7. Blurred vision.
8.