What is the mechanism of action of benazepril?

 

 Benazepril

Benazepril is an ACE(Angiotensin-converting enzyme) inhibitor. It is widely used in the treatment of high blood pressure with other medications. It is a prodrug. It is a white crystalline powder, which is soluble in water. The melting point of benazepril is 148°C to 149°C. The molecular weight of benazepril is 424.5 gm/mol.

Structure:

The molecular formula of benazepril is, [C­­­­­24H28N2O5].

Benazepril Structure

The IUPAC name of benazepril is, 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutane-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid.

Synthesis:

Benazepril Synthesis Part-1

Benazepril Synthesis Part-2

Mechanism of action:

Benazepril is an ACE inhibitor. This ACE helps in the conversion of Angiotensin-1 into Angiotensin-2. Angiotensin-2 narrows the blood vessels and blood pressure. Benazepril binds with ACE and blocks the conversion process of Angiotensin-1 into Angiotensin-2. Due to the low level of Angiotensin-2, the blood vessels are relaxed and reduce the blood pressure to a normal level.

Uses:

Benazepril is basically used in the treatment of High Blood Pressure.

Side-effects:

The overdose of benazepril shows different types of side effects like,

1. Headache.
2. Fast, irregular heartbeat.
3. fever.
4. Itching.
5. Joint or muscle pain.
6. Nausea.
7. Dizziness.
8. Diarrhea.