Bupropion|Zyban|Wellbutrin|Aplenzin|Structure|Synthesis|MOA|Uses|Side-effects

  

 Bupropion

Bupropion is an atypical antidepressant drug, which is widely used in therapy for smoking cessation. It is a pale yellow, oily liquid. Bupropion is soluble in methanol, ethanol, benzene, acetone, and ether. It is an aminoketone that is more effective than other antidepressants. It is not responsible for sleepiness, or sexual dysfunction like other antidepressants. It is a dopamine and norepinephrine reuptake inhibitor. The molecular weight of bupropion is 239.74 gm/mol and the melting point is 234°C. It is sold under the brand name Zyban, Wellbutrin, Aplenzin, and more.

Structure:

The molecular formula of bupropion is,[C­­­­­13H18NOCl].

Bupropion Structure

The IUPAC name of bupropion is 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one.

Synthesis:

Synthesis of Bupropion

Mechanism of action:

The exact mechanism of action of bupropion is not exactly clear. It is a dopamine and norepinephrine reuptake inhibitor. Bupropion binds with the norepinephrine transporter (NET) and dopamine transporter. So it enhances the neurotransmission between the nerve cells.

Uses:

It is widely used in therapy for smoking cessation. It is also used in the treatment of major depressive disorders like,

• Insomnia.
• Mental retardation.
• Suicidal initiation.
• Appetite.
• Fatigue.
• A feeling of guilt.
• Apathy.

Side-effects:

The overdose of bupropion shows different types of side effects like,

1. Headache.
2. Sore throat.
3. Dizziness.
4. Nausea.
5. Vomiting.
6. Joint pain.
7. High blood pressure.
8. Hallucination.
9. Weakness.