Bupivacaine|Structure|Synthesis|MOA|Uses|Side-effects

 

 Bupivacaine

Bupivacaine is a local anesthetic. Its blocks the sodium channel and decreases the sensation in a specific area. It is marketed under Marcaine, Marbeta, Exparel, etc. The molecular weight of bupivacaine is 288.4 gm/mol. It is a white crystalline powder, which is odorless. it is soluble in water and alcohol. It works in 10 min and lasts for 8 hours.

Structure:

The molecular formula of bupivacaine is, [C­­­­­18H28N2O].

Structure of Bupivacaine

The IUPAC name of bupivacaine is 1-butyl-N-(2,6-dimethyl phenyl) piperidine-2-carbonamide.

Synthesis:

It is synthesized from picolinic acid,

Synthesis of Bupivacaine

Mechanism of action:

Bupivacaine is a local anesthetic. its blocks the nerve in a specific area, and due to the blockage, the function of the nerve is decreased. Nerve impulses cannot be reached to the brain. Bupivacaine works in 1 hour after administration and lasts for 8 hours.

Uses:

It is a local anesthetic, which is used after or during surgery. It is a widely used anesthetic during surgery.

Side-effects:

The overdose of bupivacaine shows different types of side effects like,

1. Nausea.
2. vomiting.
3. Headache.
4. weakness
5. Fast and irregular heartbeat.
6. Blurred vision.
7. Back and joint pain.
8. No urination.
9. Pale Skin.
10. Dizziness and drowsiness,
11. Difficulty in breathing.