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 Aripiprazole

Aripiprazole is an anti-psychotic drug and dopamine receptor agonist used in the treatment of schizophrenia. It is a quinoline derivative. The brand name of aripiprazole is Abilify and Abilitate  Aripiprazole, an odorless, white to off-white crystalline powder, which is insoluble in water and soluble in dichloromethane, ethanol, etc. The molecular weight of aripiprazole is 448.4 gm/mol.

Structure:

The molecular formula of aripiprazole is,[C­­­­­23H27N3O2Cl2].

Structure of Aripiprazole

The IUPAC name of aripiprazole is,7-[4-[4-(2,3-dichlorophenyl)piperazine-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one.

Synthesis:

Synthesis of aripiprazole

Mechanism of action:

The mechanism of action of aripiprazole is different from other ant-psychotic drugs. Its exact mechanism of action is unknown. It is a dopamineD2 and serotonin 5HT1A agonist and serotonin 5HT2A receptor antagonist. Dopamine and serotonin is a neurotransmitter present in the brain that, helps in the transfer of signal from one neuron to another neuron. So aripiprazole affects this transmission of signals in the brain.

Uses:

It is used in the treatment of,

1. Schizophrenia.
2. Manic depressive illness.
3. Major depressive disorder.
4. Sometimes it is used as sleeping pills.
5. Tourette syndrome(In children).

Side-effects:

The overdose of aripiprazole shows different types of side effects like,

1. Nausea.
2. Vomiting.
3. Rapid weight gain.
4. Constipation.
5. Headache.
6. Dizziness.
7. Lightheadedness.
8. Tiredness.