Sulfapyridine|Structure|Synthesis|Mechanism of action|Uses|Side-effect|Sulfidin|Trianon|Adidlon|Ronin|Eubasin|Relbapiridina

 Sulfapyridine

Sulfapyridine is a sulfonamide antibiotic. It is a non-steroidal anti-inflammatory drug. It is derived from sulfanilamide. Sulfapyridine is an odorless, white crystalline powder with a bitter taste. It is slightly soluble in alcohol and water. The molecular weight of sulfapyridine is 249.2 gm/mol. The melting point of sulfapyridine is 376 to379°F. It is also known as, Sulfidin, Trianon, Adidlon, Ronin, Eubasin, Relbapiridina, etc.

Structure:

The molecular formula of sulfapyridine is,[C11H11N3O2s].

The IUPAC name of sulfapyridine is, 4-amino-N-pyridin-2-ylbenzene sulfonamide.

Synthesis:

Mechanism of action:

Sulfapyridine inhibits the bacterial enzyme dihydropteroate synthetase. The reaction is necessary for the bacterial organism for folic acid synthesis, by processing the substrate Para Amino Benzoic Acid(PABA). Folate is required for cells to make nucleic acids and if the DNA molecules cannot be built, the cell can not be divided.

Uses:

It is used in the treatment of pyoderma gangrenosum, dermatitis, herpetiformis, and benign mucous membrane pemphigoid. At one time it was commonly referred to as, M and B 693. it is no longer prescribed for humans. it is used to treat IgA diseases and has been used in veterinary medicine. 

Side-effects:

The overdose of sulfapyridine shows different types of side effects like,

1. Headache.
2. itching.
3. Skin rash.
4. Joint and muscle pain.
5. Sore throat.
6. Bruising.
7. Tiredness.
8. Yellow eyes.
9. Redness.
10. Pale skin.
11. Blistering.