Amodiaquine|Structure|Synthesis|Mechanism of action|Uses|Side-effects|Amodiaquin|Camoquine|Flavoquine|Miaquin|Camoquinal.

 Amodiaquine

Amodiaquine is a 4-aminoquinoline derivetives containing  anti-inflammatory   properties. It is solluble in water, sparingly  solluble in alcohol,  very slightly solluble in chloroform, ether, ben- zene. The moleculer weight of Amodiaquine is 355.9 g/mol . It is  also known as   Amodiaquin, Camoquine, Flavoquine, Miaquin, Camoquinal.

■Structure:-

The moleculer formula of Amodiaquine is, 

                                                    [C20H22ClN3O].

The IUPAC name of Amodiaquine is,

       4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol.

■Synthesis:-

■Mechanism of action:-

The plasmodicidal action of amodiaquine is not completely firm. Like other quinolin  derivetiv-

es, it  is  assumed  to inhibit  heme  pollymerase activity.  This  causes the   accumulation  of free heme  that  is toxic  to the  parasites. Its binds to the  free  heme  and  prevent  the  parasite from converting it to a less toxic form.

■Uses:-

It is used for the treating acute malarial attacks having symptoms like fever, chills and sweating. 

■Side-effects:-

The major Side-effects of amodiaquine are,

1. Gastrointestinal problems. 
2. Stomach upset.
3. Stomach pain.
4. Stomach ache.
5. Itching.
6. Hair loss.
7. Dizziness. 
8. Nausea and vomiting. 
9. Nightmares. 
10. Blurred vision. 

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