Unlocking the Potential: Exploring the Therapeutic Details of Cimetidine

Cimetidine

Cimetidine is a histamine H2 receptor. It is a colorless crystalline solid, bitter in taste, unpleasant odor. Cimetidine is freely soluble in methanol; soluble in ethanol(95%); sparingly soluble in 2-propanol; slightly soluble in water and in chloroform; practically insoluble in benzene, dichloromethane and in ether. The molecular weight is 252.3g/mol. The melting point of cimetidine is 248 to 290°F. It is also known as, Tratul, Cimal, Ulcedine, Cimetidina, Valmagen, Tagamet, Eureceptor, Gastromet etc.

Structure-

The molecular formula of cimetidine is, [C­­­­­10H16N6S] .

The IUPAC name of cimetidine is, N-cyano-N-methyl-N-(2-((5-methylimidazole-4-yl)methyl)thio)ethyl)guanidine.

Synthesis-

Uses-

*It is used to treat ulcers of the stomach and intestine and prevent them from coming after they heal.

*This medication is also used to treat certain stomach and throat problems caused by too much stomach acid and the backward flow of the stomach acid.

*It is used to decrease extra stomach acid and can help relieve symptoms such as stomach pain, heartburn persistent cough, and trouble sleeping. 

*Cimetidine is also recommended in the management of zollinger-ellison syndromes. 

Doses-

The usual oral adult dose is 400mg twice a day with breakfast and bedtime. For patients with duodenal or benign gastric ulceration a single daily dose of 800mg at bedtime is recommended. 

Side-effects -

The overdose of cimetidine shows different types of side effects,

1. Headache. 

2. Drowsiness.

3. Diarrhea.

4. Dizziness.

5. Breast enlargement.