Ranitidine|Structure|Synthesis|MOA|Uses|Side-effects

 Ranitidine

It is an Histamine H2 receptor antagonist with antacid activity. It is widely used for the treatment of acid-peptic disease and heartburn . It is also known as, Raticina, Zantac, Gastrosedol, Mecrotid,  Ptinolin, quantor, Ranidine, Xanidine, Duractin, Ranitigel,  Rantacid, Acidex, Axoban, Coralen, Ezopta, Gastrial,Istomal,Mauran,Radinat,Raniter,Verlost,Zantab,Ratic,Ranin,weidos. It is a solid particle with bitter taste. It is soluble in water 💧. The melting point is 69-70⁰c and moleculer weight is 314.41gm/mol.

Structure-

The moleculer formula of ranitidine is,    [C13H22N4O3S]

The IUPAC name of ranitidine is,

   (E)-1-N-[2-[[5-[(diethylamino) methyl]fural-yl]methylsulfonyl]ethyl]-1-N-methyl-2-                         nitroethelene-1,1-diamine

Mechanism of action-

Ranitidine competitively block H2 receptor ,because of this histamine can not act properly . The deactivation of histamine decreases cAMP formation ,which reduced the acid secretion and healing ulcer.

Dosage-

If you administrated it by,injection 💉 sollution than give 25mg/ml,by syrup than 15mg/ml, by tablet than 75,150,300 mg.

For the treatment of gastric ulcer the usual adult dose is 150mg orally every 6 hours or 50mg IM/IV every 6-8 hours. The maintainance dose is 150mg orally every 12 hours.

For the treatment of hyper secratory condition  the usual adult dose is 150mg orally  every 12hours up to 6g/day used.

For the treatment of erosive esophagitis the usual adult dose is 150mg orally every 6 hours or 50mg IM/IV every 6-8hours and the maintainance dose is 150mg orally every 12 

hours.

Uses-

It is used in the treatment of ulcers ,gastroesophageal reflux disease (GERD) ,a condition in which backward flow of fluid from the stomach causes heartburn and injury of esophagus. 

Side-effects-

The major Side-effects of ranitidine are,

• Skin rash. 
• Constipation. 
• Diarrhea. 
• Dizziness. 
• Drowsiness. 
• Headache. 
• Nausea and vomiting. 
• Stomach cramps.

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