Azelastine|Optivar||Structure|Synthesis|MOA|Uses|Side-effects

  

 Azelastine

It is a histamine-1(H-1) receptor antagonist which is used in the treatment of several allergic reactions, like asthma, hay fever, conjunctivitis, etc. It is a second-generation antihistamine. The brand name is Optivar. Azelastine also contains anti-inflammatory effects. it is a pthalazine derivative. Azelastine is bitter in taste, odorless, white crystalline solid, which is soluble in water and methylene chloride. The molecular weight of azelastine is 381.90 gm/mol.

Structure:

The molecular formula of azelastine is,[C­­­­­22H24NO₃Cl].

Structure

The IUPAC name of azelastine is 4-[(4-chlorophenyl)methyl]-2-(1-methylzepam-4-yl)pthalazine-1-one.

Synthesis:

Synthesis

Mechanism of action:

Azelastine is an H1 (histamine-1) receptor antagonist, so it blocks the effect of the histamine receptor. Due to this, histamine-mediated allergic symptoms are cured. It also affects anti-inflammatory effects by inhibiting inflammatory mediators.

Uses:

1. Asthma.
2. Allergic rhinitis(hay fever).
3. Conjunctivitis.
4. Skin problems.
5. Vasomotor rhinitis.
6. Coughing

Side-effects:

The overdose of azelastine shows different types of side effects like,

1. Sneezing.
2. Ear infections.
3. Sore throat.
4. Headache.
5. Difficulty in breathing.
6. Bitter taste in the mouth.
7. Fever.
8. Respiratory tract infections.
9. Nose pain.
10. Hives.