Sulfacetamide|Structure|Synthesis|Mechanism of action|Uses|Side-effects|Acetocid|Alesten|Albamine|Albusid|Sebizon|Opthel-S|Klaron|Sulfacet|Acetosulfamine

 Sulfacetamide

It is a sulfonamide antibacterial agent and sulfanyl acetamide derivative. It is used in the treatment of urinary tract infections and some skin infections. It is a white powder, which is slightly soluble in water the molecular weight of sulfacetamide is 214.2 gm/mol and the melting point is, 360 to 363°C. It is also known as, Acetocid, Alesten, Albamine, Albusid, Sebizon, Opthel-S, Klaron, Sulfacet, Acetosulfamine, etc.

Structure:

The molecular formula of sulfacetamide is,[C8H10N2O3S].

The IUPAC name of sulfacetamide is N-(4-aminophenyl)sulfonyl acetamide.

Synthesis:

The reaction between 4-aminobenzene sulphonamide with acetic anhydride and controlled H2O produced Sulfacetamide.

Mechanism of action:

Sulfacetamide reacts with a bacterial folic acid synthesis which is very important for the bacterial organism. It interferes with folic acid synthesis by inhibiting Para-Amino benzoic Acid(PABA), which is necessary for bacterial growth.

Uses:

It is used in the treatment of several infections like Conjunctivitis, Vaginitis, Blepharitis, Keratitis, etc.

Side-effects:

The overdose of sulfacetamide shows different types of adverse effects like,

1. Fever.
2. Joint pain.
3. Sores in the mouth.
4. Cracked and dry skin.
5. Rash hives.
6. Itching.
7. Difficulty in breathing.
8. yellow skin or eyes.