Atenolol|Structure|Synthesis|MOA|Uses|Side-effects|Atenblock|Betablock|Atenolol|Atenolin|

  

 Atenolol

Atenolol is a synthetic cardioselective beta-blockers, which is used in the treatment of high blood pressure(hypertension). It is a β-1 receptor antagonist. It is an ethanolamine compound. it is also known as, co-tenidone. It is a colorless, white, crystalline powder, which is soluble in acetic acid, ethanol, methanol, etc, and insoluble in chloroform. it is soluble in water. The molecular weight of atenolol is 266 gm/mol. 

Structure:

The molecular formula of atenolol is, [C­­­­­14H22N₂O₃].

Atenolol Structure

The IUPAC name of atenolol is 2-[4-[2-hydroxy-3-(propane-2-yl amino)propoxyl]phenyl]acetamide.

Synthesis:

Atenolol Synthesis

Mechanism of action:

Atenolol is a synthetic cardioselective beta-blocker that binds with the β1 receptor, which is present in the heart and vascular smooth muscle. it blocks the action of epinephrine. Due to this blood pressure, myocardial contractility and heart rate decreased.

Uses:

• It is used in the treatment of several diseases like Hypertension(High blood pressure), and arrhythmia (irregular heartbeat).
• Atenolol is used to prevent heart attacks and strokes.
• It is used in the treatment of chest pain caused by angina.

Side-effects:

The overdose of atenolol shows several side effects like,

1. Dizziness.
2. Chest pain.
3. Slow heartbeat.
4. Lightheadedness.
5. Rapid weight gain.
6. Nausea.
7. Itching on the face, and throat.