Amoxycillin|Structure|Synthesis|MOA|Uses|Side-effects|Amolin|Amoxil|Amoclen|BRL-233

  

 Amoxycillin

Amoxycillin is a broad-spectrum antibiotic used in the treatment of several bacterial infections like pneumonia, Urinary tract infection, skin infection, etc. It is a semi-synthetic derivative of 6-APA (6-Amino penicillanic acid). Amoxycillin is an odorless, solid crystalline powder, which is bitter in taste and soluble in water, methanol. The molecular weight of Amoxycillin is 365 gm/mol. It is also known as, Amolin, Amoxil, Amoclen, BRL-233, etc.

Structure:

The molecular formula of Amoxycillin is,[C­­­­­16H19N3O5S].

The IUPAC name of amoxycillin is, (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxy phenyl)acetyl]amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.

Synthesis:

Mechanism of action:

Amoxycillin is an β-lactam penicillin antibiotic. Amoxycillin binds with PBPs(Penicillin Binding Proteins). It inhibits the transpeptidase enzyme, which is responsible for the making of the bacterial cell wall. Amoxycillin inhibits the third and final stage of bacterial cell wall synthesis in binary fusion, due to this Amoxycillin is bacteriolytic.

Uses:

Amoxycillin is used in the treatment of several bacterial infections like,

1. Urinary Tract Infections.
2. Pneumonia.
3. ENT infections.
4. Stomach ulcer caused by helicobacter pylori in combination with clarithromycin.
5. Tonsillitis.
6. Gonorrhea.

Side-effects:

The overdose of amoxicillin shows different types of side effects like,

1. Blood in the urine.
2. Diarrhea.
3. Dark urine.
4. Dizziness.
5. Black cough.
6. Tarry stools.
7. Chest pain.
8. Stomach cramps.
9. Difficulty in breathing.
10. Fever.
11. Hives.
12. Itching.
13. Muscle ache.
14. Sore throat.
15. Rash