Ornidazole|Structure|Synthesis|Mechanism of action|Uses|Side-effects|Ornidazolum|Ornidazole levo|Madelen|Tiberal

Ornidazole

 Ornidazole is an anti-protozoal drug with broad spectrum activity against protozoa. It is an imidazole derivative. It is a colorless crystalline powder which is soluble in ethanol and water. The moleculer weight of ornidazole is 219.6 gm/mol. The melting point is 77.5 to 80 degree C. It is also known as, Ornidazolum, Ornidazole levo, Madelen, Tiberal etc.

Structure:

The molecular weight of ornidazole is,[C7H10ClN3O3].

The IUPAC name of ornidazole is,1-chloro-3-(2-methyl-5-nitroimidazol-1-yl)propan-2-ol.

Synthesis:

Mechanism of action:

The mechanism of action of ornidazole is not exactly clear. By the diffusion process the drug is entered in the human cell. The drug nitro group is reduced to nitro radical by flavodoxin or ferredoxin enzyme. The ornidazole is selective to reduction of the nitrogen group by the help of redox pottential of electron transport portion of anaerobic microorganism. This reduction of nitrogen produced toxic acetamide and N-(2-hydroxyethyl)oxamic acid, which damage the fungal DNA replication process.

Uses:

It is used in the treatment of,

1. Vaginitis.

2. Amoebic liver abscess.

3. Giardiasis.

4. Trichomoniasis.

5. Crohn,s disease.

6. Dysentery.

Side-effects:

The overdose of ornidozole shows differents types of side-effects like, 

1. Jaundice.

2. Severe dizziness.

3. Tingling sensetion.

4. Confusion.

5. Servere diarrhoea.

6. Tremors.

7. Rigidity.

8. Siezures.

                     ..........THEEND..........