Diethylcarbamazine citrate|Structure|Synthesis|Mechanism of action|Uses|Side-effect|Dicarocide|Ethodryl citrate|Franozan|Filazine|Diroform|Eosinopin|Franocide|Caritrol|Filazine|longicid|Ditrazinum|Filarabits

 Diethylcarbamazine Citrate

Diethylcarbamazine citrate (DCE) is an anthelmintics drug, which is used in the treatment of ascariasis, loiasis, etc. It is an odorless, bitter, crystalline solid. It is soluble in alcohol and insoluble in benzene and chloroform. It is a piperazine carboxamide. The molecular weight of Diethylcarbamazine citrate is 391.4 gm/mol. The melting point is 285.5 to 289°F. It is also known as, Dicarocide, Ethodryl citrate, Franozan, Filazine, Diroform, Eosinopin, Franocide, Caritrol, Filazine, longicid, Ditrazinum, Filarabits, etc.

Structure:

The molecular formula of Diethylcarbamazine citrate is,[C16H29N3O8].

The IUPAC name of Diethylcarbamazine citrate is, N, N-diethyl-4-methylpiperazine-1-carboxamide-2-hydroxypropane-1,2,3-tricarboxilic acid.

Synthesis:

Mechanism of action:

The activeness against Brugia malayi depends on the Cylo Oxygenase Pathway and nitric oxide synthase. It also inhibits the arachidonic acid metabolite pathway and affects on the 5-lipoxygenase pathway. This drug makes the parasite more susceptible to innate immune attack but does not kill the parasite.

Uses:

It is used in the treatment of,

1. River Blindness.
2. Roundworm infection.
3. Tropical eosinophilia.
4. Lymphatic filariasis.
5. loiasis.

Side-effects:

The overdose of Diethylcarbamazine citrate shows different types of adverse effects like,

1. Rash.
2. Dizziness.
3. Nausea.
4. Vomiting.
5. Fever.
6. Swollen glands in the neck.

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