Eflornithine|Structure|Synthesis|Mechanism of Action|Uses|Side-effects|Vaniqua|Eflornithine hydrochloride|DFMO|DFMO HCl

 Eflornithine

Eflornithine is an antiprotozoal drug, which is used in the treatment of facial hirsutism ( excessive hair growth on face in woman). It is prescription drug, the World Health Organisation (WHO) added this medicine in 2009. It is a creamy formulation. The molecular weight of eflornithine is 182.1 gm/mol. The brand name of eflornithine is, Vaniqua.  It is also known as, Eflornithine hydrochloride, DFMO, DFMO HCl  etc.

Structure:

The molecular formula of eflornithine is, [C6H12ClF2N2O2] .

The IUPAC name of eflornithine is, 2,5-diamino-2-(difluromethyl)pentanoic acid .

Synthesis:

Mechanism of Action:

Eflornithine is binds with Ornithine Decarboxylase (ODC) and inhibiting anagen phase of hair production. That prevents the natural substrate ornithine from accesing the active site.

Uses:

It is used in the treatment of excessive hair growth on face and body in woman (Facial Hirsutism).

 Side-effects:

The overdose of eflornithine shows different types of side-effects like,

1.Ingrown hair.

2. Itching.

3. Hair loss.

4. Dry and tingling skin.

5. Stinging.

6. Rash.

7. Burning skin.

8. Headache.

9. Acne.

10. Pimple on skin.